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To understand the inflammatory microenvironment and microbiome factors Synthetic Steroids SARMs are synthetic chemicals designed to mimic the effects of testosterone and other anabolic steroids, and are used as anabolic and anti-catabolic agents (for example, for treatment of prostate problems). These are similar to the hormones that humans produce: Testosterone produces changes in the central nervous system, which cause erectile dysfunction and increases the risk of developing cancer. Although this risk is reduced by treatment with anabolic steroids, it does lead to the development of male pattern baldness. SARMs have anabolic effects on the liver, muscle, heart and the heart failure syndrome (a potentially lethal disorder that is caused by abnormal heart rate and blood pressure). Testosterone also increases the risk of prostate cancer. There are two main types of SARMs; 1) analogs and 2) mimics. Analogs include a group of synthetic materials that behave like the naturally found steroids; e.g in a human being if one were to take a synthetic steroid it would be identical to one found in a natural source (e.g anabolic steroid). These include some SARMs, for example, 5α-reductase inhibitors, nandrolone decanoate and 5alpha-reductase inhibitors. Some SARMs have also been found to have anabolic effects which are unique to them. They include aldosterone and aldosterone analogs; and the anabolic steroid nandrolone decanoate, which has been shown to modulate the immune response and increase the risk of developing cancer. All the major SARMs have been shown to have adverse interactions: 1) with their endogenous substrates, especially with their anabolic hormones, for example 5α-reductase inhibitors 2) with other drug-metabolizing enzymes, for example the cytochrome P450 (CYP) enzyme group 3) with a variety of other metabolites, for example 5α-reductive steroids, steroids with anti-obesity and anti-fatty liver effects, such as cytochrome P450 3A4, the anabolic steroid dihydrotestosterone (DMHT), the cytochrome P450 (CYP)3B group 4) with a variety of enzymes, for example the glutathione S-transferase (GST) enzyme group 5) with proteases or proteomic enzymes, for example the GST/GST group 1) to regulate cellular homeostasis, including DNA repair, 2) to affect cellular growth, such as growth hormone, growth hormone receptor, osteocalcin, and IGF-1, 3) to affect cellular death, such as hypoxia, oxygen Similar articles: